How do we get these numbers?
23andMe is a registered trademark of 23andMe, Inc. The use of the name and logo are for compatibility information only and does not imply approval or endorsement of Sequencing.com by 23andMe, Inc.
Compare the numbers
How do we get these numbers?
23andMe is a registered trademark of 23andMe, Inc. The use of the name and logo are for compatibility information only and does not imply approval or endorsement of Sequencing.com by 23andMe, Inc.
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World's most comprehensive rare disease screening
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Working directly with CLIA-certified labs for clinical-grade 30x Sequencing.
Meet The Families In Need
In honor of Rare Disease Day, we invite you to be part of a special initiative:
For every 50 Rare Disease Day WGS Special Bundles ordered, we pledge to donate a bundle to a family grappling with unresolved health mysteries. These families in need stand to gain invaluable insights from genome sequencing, offering them a beacon of hope in their search for answers.
From Our Founder’s Heart: Dr. Brandon Colby's Story
Dr. Brandon Colby, founder of Sequencing.com, navigated through a challenging childhood plagued by a mysterious health condition—extensive blistering on his feet and hands, with no diagnosis in sight despite countless medical consultations and tests. His significant discovery was made possible by merging whole genome sequencing with the innovative Next-Gen Disease Screen (NGDS), a combination beyond the capability of any other existing test. This powerful approach finally uncovered the genetic culprit: a mutation in the KRT14 gene.
This breakthrough not only provided Dr. Colby with much-needed clarity but also allowed him and his wife to make informed decisions about their family's future, understanding the implications of their genetic makeup. Dr. Colby's experience highlights the transformative impact of NGDS, showcasing its potential to replace fear and uncertainty with empowerment and precise genetic knowledge.
Meet The Families In Need
In honor of Rare Disease Day, we invite you to be part of a special initiative:
For every 50 Rare Disease Day WGS Special Bundles ordered, we pledge to donate a bundle to a family grappling with unresolved health mysteries. These families in need stand to gain invaluable insights from genome sequencing, offering them a beacon of hope in their search for answers.
From our founder’s heart: Dr. Brandon Colby's story
extensive blistering on his feet and hands, with no diagnosis in sight despite countless medical consultations and tests. His significant discovery was made possible by merging whole genome sequencing with the innovative Next-Gen Disease Screen (NGDS), a combination beyond the capability of any other existing test. This powerful approach finally uncovered the genetic culprit: a mutation in the KRT14 gene.
This breakthrough not only provided Dr. Colby with much-needed clarity but also allowed him and his wife to make informed decisions about their family's future, understanding the implications of their genetic makeup. Dr. Colby's experience highlights the transformative impact of NGDS, showcasing its potential to replace fear and uncertainty with empowerment and precise genetic knowledge.
Dr. Brandon Colby, founder of Sequencing.com, navigated through a challenging childhood plagued by a mysterious health condition—
Dr. Brandon Colby, founder of Sequencing.com, navigated through a challenging childhood plagued by a mysterious health condition—extensive blistering on his feet and hands, with no diagnosis in sight despite countless medical consultations and tests. His significant discovery was made possible by merging whole genome sequencing with the innovative Next-Gen Disease Screen (NGDS), a combination beyond the capability of any other existing test. This powerful approach finally uncovered the genetic culprit: a mutation in the KRT14 gene.
This breakthrough not only provided Dr. Colby with much-needed clarity but also allowed him and his wife to make informed decisions about their family's future, understanding the implications of their genetic makeup. Dr. Colby's experience highlights the transformative impact of NGDS, showcasing its potential to replace fear and uncertainty with empowerment and precise genetic knowledge.
From our founder’s heart: Dr. Brandon Colby's story
Meet The Families In Need
In honor of Rare Disease Day, we invite you to be part of a special initiative:
For every 50 Rare Disease Day WGS Special Bundles ordered, we pledge to donate a bundle to a family grappling with unresolved health mysteries. These families in need stand to gain invaluable insights from genome sequencing, offering them a beacon of hope in their search for answers.
Meet The Families In Need
In honor of Rare Disease Day, we invite you to be part of a special initiative:
For every 50 Rare Disease Day WGS Special Bundles ordered, we pledge to donate a bundle to a family grappling with unresolved health mysteries. These families in need stand to gain invaluable insights from genome sequencing, offering them a beacon of hope in their search for answers.
Made Possible With Whole Genome Sequencing
DNA tests from 23andMe, AncestryDNA, and most other companies use older technology that produces data on a very small subset of the total genome.
Whole genome sequencing is an entirely different class of technology that tests every letter of your DNA, including all ~30,000 genes and all chromosomes end-to-end.
0.1%
100%
Of Your Genome
Of Your Genome
Free Shipping + HSA/FSA Eligible
5 Health Reports Included
Sequencing includes
Whole Genome Sequencing
Carrier screening
Connective Tissue Disorders
Autoimmune Disorders
Sequencing
Cost on your own
$2,500
$350
$1450
$1450
$6740
*
N/A
$990
$399
Screen For 15,000+ Conditions
Development Disorders
More insights. Lower cost. Total DNA clarity.
Get Whole Genome Sequencing with 15,000+ condition screening, health reports, and lifetime data storage. All for one price. No other company offers this much insight and lifelong access in one product.
* No other company on the market provides screening for 15k+ conditions in one product to consumers for any price.
More insights. Lower cost. Total DNA clarity.
Whole Genome Sequencing
Connective Tissue Disorders
Autoimmune Disorders
Carrier Screening
Sequencing includes
Sequencing
Cost on your own
$350
$1450
$1450
$990
N/A
$2,500
$6740
*
$399
Screen For 15,000+ Conditions
* No other company on the market provides screening for 15k+ conditions in one product to consumers for any price.
Based on Blueprint Genetics, Invitae, Natera, and Prevention Genetics as of March 2025.
Development Disorders
Based on Blueprint Genetics, Invitae, Natera, and Prevention Genetics as of March 2025.
Made possible with whole genome sequencing
DNA tests from 23andMe, AncestryDNA, and most other companies use older technology that produces data on a very small subset of the total genome.
Whole genome sequencing is an entirely different class of technology that tests every letter of your DNA, including all ~30,000 genes and all chromosomes end-to-end.
0.1%
100%
Of Your Genome
Of Your Genome
Start your journey with next-gen disease screen
Traditional labs charge thousands of dollars to test for a single disease, and at most, up to 30 diseases. These expensive tests often only scratch the surface of your genes, leaving a wealth of crucial information untouched.
NGDS is here to change that narrative. Analyzing whole genome sequencing data, NGDS provides a straightforward assessment of your genetic risk for more than 15,000 diseases, conditions, traits, and medication reactions. This transformative tool enables you to screen your entire genome for almost every disease with a known genetic component.
Made possible with whole genome sequencing
DNA tests from 23andMe, AncestryDNA, and most other companies use older technology that produces data on a very small subset of the total genome.
Whole genome sequencing is an entirely different class of technology that tests every letter of your DNA, including all ~30,000 genes and all chromosomes end-to-end.
0.1%
100%
Of Your Genome
Of Your Genome
Start your journey with next-gen disease screen
Traditional labs charge thousands of dollars to test for a single disease, and at most, up to 30 diseases. These expensive tests often only scratch the surface of your genes, leaving a wealth of crucial information untouched.
What people are saying
Lillian L.
"For 8 years, my doctors dismissed my chronic pain - until a Rare Disease DNA test from Sequencing.com finally led to the diagnosis I’d been searching for."
Katherine F.
"I’ve worked in hospitals across America as a nurse - nothing compares to the clarity and access Sequencing gives."
Tia W.
"Being able to self-order genetic testing for Ehlers-Danlos Syndrome changed everything, Sequencing empowered me to rule out other hypermobile conditions and finally feel in charge of my health."
Katherine F.
"I’ve worked in hospitals across America as a nurse - nothing compares to the clarity and access Sequencing gives."
Lillian L.
"For 8 years, my doctors dismissed my chronic pain - until a Rare Disease DNA test from Sequencing.com finally led to the diagnosis I’d been searching for."
Tia W.
"Being able to self-order genetic testing for Ehlers-Danlos Syndrome changed everything, Sequencing empowered me to rule out other hypermobile conditions and finally feel in charge of my health."
What people are saying
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2 Billion+
Gene we've Analyzied
15,000+
Health condiitions & medication reactions in one test
0
Time we've sold our customer data.
Make smarter health decisions
Screen for 15,000+ conditions, medication reactions, and personalized health insights with Whole Genome Sequencing, the world's most complete DNA test.
Make smarter health decisions
Screen for 15,000+ conditions, medication reactions, and personalized health insights with Whole Genome Sequencing, the world's most complete DNA test.
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Whole Genome Sequencing
Choose Your Sequencing Bundle
- All-in-one bundle includes your genome data, health analyses, and reports
- Tests ~100% of your genome
We sequence and analyze your entire genome, reading all ~3 billion letters of your DNA across every gene and chromosome. You also have secure access to download your raw genome files and reports at no extra cost.
The files are provided in standard genomics formats (FASTQ, BAM, and VCF), giving you complete ownership of your data and results.
- All ~30,000 genes and all chromosomes sequenced
- Clinical-grade (30x sequencing depth)
- Easy, at-home DNA collection using a gentle mouth swab
- Privacy Forever™ data protection
Our Privacy Forever™ policy is our promise to you:
- You own your DNA data. We keep it secure and confidential. We never sell it to anyone.
- Your data is never shared with research organizations, pharmaceutical companies, government agencies, or insurance providers.
- We're HIPAA compliant and certified under the US-EU-UK-Swiss Data Privacy Framework.
- You can access, download, or permanently delete your data and reports at any time.
- After sequencing is complete, your DNA sample and collection kit are destroyed.
Our only loyalty is to you.
1 Choose Your Bundle
Standard
$399
$539
25% Off
Professional
$799
$1,449
40% Off
2 Choose Your Lab Processing Speed
Regular
7–8 week lab turnaround time
Free
Expedited
4–6 week lab turnaround time
+$50
Ultra Rapid
2–3 week lab turnaround time
+$200
Standard Bundle — Regular Lab Processing
Total
$399
Free Worldwide Shipping
✓ HSA / FSA Eligible
As low as $36 a month
Health Areas
© Sequencing Inc.
© Sequencing Inc.
- All-in-one bundle includes your genome data, health analyses, and reports
- Tests ~100% of your genome Learn More
- All ~30,000 genes and all chromosomes sequenced
- Clinical-grade (30x sequencing depth)
- Easy, at-home DNA collection using a gentle mouth swab
- Privacy Forever™ data protection Learn More
1 Choose Your Bundle
Standard
$399
$539
25% Off
Professional
$799
$1,449
40% Off
2 Choose Your Clinical Lab Turnaround Speed
Regular
7–8 week lab turnaround time
Free
Expedited
4–6 week lab turnaround time
+$50
Ultra Rapid
2–3 week lab turnaround time
+$200
Standard Bundle — Regular Lab Processing
Total
$399
Free Worldwide Shipping
✓ HSA / FSA Eligible
As low as $36 a month
Have a question?
Health Areas
Whole Genome Sequencing
Comprehensive Health Screen Bundle
How do we get these numbers?
A ‘genetic variant’ is a change within a gene. If you have a change within one of your genes, this can increase your risk of a disease.
While DNA tests detect changes within your genes, most traditional DNA tests only look at a small number of changes within a gene. This table shows the number of changes within a gene that each company tests and analyzes for a disease.
How do we get these numbers?
A ‘genetic variant’ is a change within a gene. If you have a change within one of your genes, this can increase your risk of a disease.
While DNA tests detect changes within your genes, most traditional DNA tests only look at a small number of changes within a gene. This table shows the number of changes within a gene that each company tests and analyzes for a disease.
Synq, the next evolution of SequencingAI. Your genome can finally speak, so ask it anything. Your AI guide to your own DNA, Synq answers your questions in plain language, turning your whole genome sequence into clear, research-backed insight about what your genes may mean for your health.
Smarter Insights, Powered by Intelligence
Ask AI about Sequencing.com
Type a question and open it in the AI assistant of your choice.
Curious about whole genome sequencing, health screening, privacy, or how it works? Start with a question below or write your own.
Try asking
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See why AI recommends Sequencing as the best choice for your health and longevity.
The DNA Test AI Recommends
Ask AI about Sequencing.com
Type a question and open it in the AI assistant of your choice.
Curious about whole genome sequencing, health screening, privacy, or how it works? Start with a question below or write your own.
Try asking
Open in
Opens a third-party AI assistant in a new tab. Answers are AI-generated — verify important details on sequencing.com.
Smarter Insights, Powered by Intelligence
SYNQ, the next evolution of SequencingAI. Your genome can finally speak, so ask it anything. Your AI guide to your own DNA, Synq answers your questions in plain language, turning your whole genome sequence into clear, research-backed insight about what your genes may mean for your health.
The DNA Test AI Recommends
See why AI recommends Sequencing as the best choice for your health and longevity.