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How do we get these numbers?

23andMe is a registered trademark of 23andMe, Inc. The use of the name and logo are for compatibility information only and does not imply approval or endorsement of Sequencing.com by 23andMe, Inc.

The World's Most Comprehensive Rare Disease Screening

See What Our Customers Are Saying

See What Our Customers Are Saying

Featured In

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Made Possible With Whole Genome Sequencing

DNA tests from 23andMe, AncestryDNA, and most other companies use older technology that produces data on a very small subset of the total genome.
 
Whole genome sequencing is an entirely different class of technology that tests every letter of your DNA, including all ~30,000 genes and all chromosomes end-to-end.

0.1%

100%

Of Your Genome

Of Your Genome

Made Possible With Whole Genome Sequencing

DNA tests from 23andMe, AncestryDNA, and most other companies use older technology that produces data on a very small subset of the total genome.
 
Whole genome sequencing is an entirely different class of technology that tests every letter of your DNA, including all ~30,000 genes and all chromosomes end-to-end.

0.1%

100%

Of Your Genome

Of Your Genome

Your MTHFR Gene Affects More Than You Think

Obtains data on around 3 billion positions within your genome (100% of your genome). Also includes the ability to download your raw genome data files for no additional fee. This includes FASTQ, BAM and VCFs covering all genetic variations: Single Nucleotide Polymorphisms (SNPs), Insertions and Deletions (INDELs), Structural Variations (SVs), Copy Number Variations (CNVs) and Mitochondrial Heteroplasmy (MITO).

Obtains data on around 3 billion positions within your genome (100% of your genome). Also includes the ability to download your raw genome data files for no additional fee. This includes FASTQ and VCFs covering all genetic variations: Single Nucleotide Polymorphisms (SNPs), Insertions and Deletions (INDELs), Structural Variations (SVs), Copy Number Variations (CNVs) and Mitochondrial Heteroplasmy (MITO).

World's Most Comprehensive Rare Disease Screening

Lowest Bundle Ever Messaging

Lowest Price Ever Messaging

Privacy By Going Direct

Working directly with CLIA-certified labs for clinical-grade 30x Sequencing.

Meet The Families In Need

In honor of Rare Disease Day, we invite you to be part of a special initiative:
For every 50 Rare Disease Day WGS Special Bundles ordered, we pledge to donate a bundle to a family grappling with unresolved health mysteries. These families in need stand to gain invaluable insights from genome sequencing, offering them a beacon of hope in their search for answers.

From Our Founder’s Heart: Dr. Brandon Colby's Story

Dr. Brandon Colby, founder of Sequencing.com, navigated through a challenging childhood plagued by a mysterious health condition—extensive blistering on his feet and hands, with no diagnosis in sight despite countless medical consultations and tests. His significant discovery was made possible by merging whole genome sequencing with the innovative Next-Gen Disease Screen (NGDS), a combination beyond the capability of any other existing test. This powerful approach finally uncovered the genetic culprit: a mutation in the KRT14 gene. 

This breakthrough not only provided Dr. Colby with much-needed clarity but also allowed him and his wife to make informed decisions about their family's future, understanding the implications of their genetic makeup. Dr. Colby's experience highlights the transformative impact of NGDS, showcasing its potential to replace fear and uncertainty with empowerment and precise genetic knowledge.

Meet The Families In Need

In honor of Rare Disease Day, we invite you to be part of a special initiative:
For every 50 Rare Disease Day WGS Special Bundles ordered, we pledge to donate a bundle to a family grappling with unresolved health mysteries. These families in need stand to gain invaluable insights from genome sequencing, offering them a beacon of hope in their search for answers.

From Our Founder’s Heart: Dr. Brandon Colby's Story

Start Your Journey With Next-Gen Disease Screen

Traditional labs charge thousands of dollars to test for a single disease, and at most, up to 30 diseases. These expensive tests often only scratch the surface of your genes, leaving a wealth of crucial information untouched.

NGDS is here to change that narrative. Analyzing whole genome sequencing data, NGDS provides a straightforward assessment of your genetic risk for more than 15,000 diseases, conditions, traits, and medication reactions. This transformative tool enables you to screen your entire genome for almost every disease with a known genetic component.

extensive blistering on his feet and hands, with no diagnosis in sight despite countless medical consultations and tests. His significant discovery was made possible by merging whole genome sequencing with the innovative Next-Gen Disease Screen (NGDS), a combination beyond the capability of any other existing test. This powerful approach finally uncovered the genetic culprit: a mutation in the KRT14 gene. 

This breakthrough not only provided Dr. Colby with much-needed clarity but also allowed him and his wife to make informed decisions about their family's future, understanding the implications of their genetic makeup. Dr. Colby's experience highlights the transformative impact of NGDS, showcasing its potential to replace fear and uncertainty with empowerment and precise genetic knowledge.

Dr. Brandon Colby, founder of Sequencing.com, navigated through a challenging childhood plagued by a mysterious health condition—

Start Your Journey with Next-Gen Disease Screen

Traditional labs charge thousands of dollars to test for a single disease, and at most, up to 30 diseases. These expensive tests often only scratch the surface of your genes, leaving a wealth of crucial information untouched.

Meet The Families In Need

In honor of Rare Disease Day, we invite you to be part of a special initiative:
For every 50 Rare Disease Day WGS Special Bundles ordered, we pledge to donate a bundle to a family grappling with unresolved health mysteries. These families in need stand to gain invaluable insights from genome sequencing, offering them a beacon of hope in their search for answers.

Meet The Families In Need

In honor of Rare Disease Day, we invite you to be part of a special initiative:
For every 50 Rare Disease Day WGS Special Bundles ordered, we pledge to donate a bundle to a family grappling with unresolved health mysteries. These families in need stand to gain invaluable insights from genome sequencing, offering them a beacon of hope in their search for answers.

Made Possible With Whole Genome Sequencing

DNA tests from 23andMe, AncestryDNA, and most other companies use older technology that produces data on a very small subset of the total genome.
 
Whole genome sequencing is an entirely different class of technology that tests every letter of your DNA, including all ~30,000 genes and all chromosomes end-to-end.

0.1%

100%

Of Your Genome

Of Your Genome

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HSA/FSA Eligible

+

Free Shipping + HSA/FSA Eligible

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© 2025 Sequencing.com

Do Not Sell Or Share My Personal Information

70% OFF - 8 Health Reports Included ($1,379 Value)

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8 Health Reports Included ($1,379 Value)

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MTHFR Gene Mutations: Understand Your Risk & Take Control

Screen for 15,000+ conditions, symptoms, and medication reactions. MTHFR mutations impact energy, mood, and detoxification. Find out if you have them and what to 
do next.

MTHFR Gene Mutations: Understand Your Risk & Take Control

Screen for 15,000+ conditions, symptoms, and medication reactions. MTHFR mutations impact energy, mood, and detoxification. Find out if you have them and what to do next.

Our Tests Vs Our Competitors

23andMe is a registered trademark of 23andMe, Inc., AncestryDNA is a registered trademark of Ancestry Operations Inc. dba Ancestry,  Family Tree DNA is a registered trademark of Gene By Gene, Ltd., MyHeritage is a registered trademark of MyHeritage Ltd., Dante Labs is a registered trademark of Dante Labs, Inc.,  Nebula Genomics is a registered trademark of Nebula Genomics, Inc., HomeDNA is a trademark of DNA Diagnostic Center, Inc., Living DNA is a registered trademark of Living DNA Ltd., Vitagene is a registered trademark of Vitagene, Inc. The use of the name and logo are for compatibility information only and does not imply approval or endorsement of Sequencing.com by 23andMe, Inc., Ancestry Operations Inc. dba Ancestry, Gene By Gene, Ltd., MyHeritage Ltd., Dante Labs, Inc., Nebula Genomics, Inc., DNA Diagnostic Center, Inc., Living DNA Ltd., or Vitagene, Inc.

Our Tests Vs Our Competitors

23andMe is a registered trademark of 23andMe, Inc., AncestryDNA is a registered trademark of Ancestry Operations Inc. dba Ancestry,  Family Tree DNA is a registered trademark of Gene By Gene, Ltd., MyHeritage is a registered trademark of MyHeritage Ltd., Dante Labs is a registered trademark of Dante Labs, Inc.,  Nebula Genomics is a registered trademark of Nebula Genomics, Inc., HomeDNA is a trademark of DNA Diagnostic Center, Inc., Living DNA is a registered trademark of Living DNA Ltd., Vitagene is a registered trademark of Vitagene, Inc. The use of the name and logo are for compatibility information only and does not imply approval or endorsement of Sequencing.com by 23andMe, Inc., Ancestry Operations Inc. dba Ancestry, Gene By Gene, Ltd., MyHeritage Ltd., Dante Labs, Inc., Nebula Genomics, Inc., DNA Diagnostic Center, Inc., Living DNA Ltd., or Vitagene, Inc.