How do we get these numbers?
23andMe is a registered trademark of 23andMe, Inc. The use of the name and logo are for compatibility information only and does not imply approval or endorsement of Sequencing.com by 23andMe, Inc.
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Featured in
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World's most comprehensive rare disease screening
No Insurance Companies
Keep Your Results Anonymous
Save Thousands Without A Doctor's Lab Order
Privacy By Going Direct
Working directly with CLIA-certified labs for clinical-grade 30x Sequencing.
Meet The Families In Need
In honor of Rare Disease Day, we invite you to be part of a special initiative:
For every 50 Rare Disease Day WGS Special Bundles ordered, we pledge to donate a bundle to a family grappling with unresolved health mysteries. These families in need stand to gain invaluable insights from genome sequencing, offering them a beacon of hope in their search for answers.
From Our Founder’s Heart: Dr. Brandon Colby's Story
Dr. Brandon Colby, founder of Sequencing.com, navigated through a challenging childhood plagued by a mysterious health condition—extensive blistering on his feet and hands, with no diagnosis in sight despite countless medical consultations and tests. His significant discovery was made possible by merging whole genome sequencing with the innovative Next-Gen Disease Screen (NGDS), a combination beyond the capability of any other existing test. This powerful approach finally uncovered the genetic culprit: a mutation in the KRT14 gene.
This breakthrough not only provided Dr. Colby with much-needed clarity but also allowed him and his wife to make informed decisions about their family's future, understanding the implications of their genetic makeup. Dr. Colby's experience highlights the transformative impact of NGDS, showcasing its potential to replace fear and uncertainty with empowerment and precise genetic knowledge.
Meet The Families In Need
In honor of Rare Disease Day, we invite you to be part of a special initiative:
For every 50 Rare Disease Day WGS Special Bundles ordered, we pledge to donate a bundle to a family grappling with unresolved health mysteries. These families in need stand to gain invaluable insights from genome sequencing, offering them a beacon of hope in their search for answers.
Meet The Families In Need
In honor of Rare Disease Day, we invite you to be part of a special initiative:
For every 50 Rare Disease Day WGS Special Bundles ordered, we pledge to donate a bundle to a family grappling with unresolved health mysteries. These families in need stand to gain invaluable insights from genome sequencing, offering them a beacon of hope in their search for answers.
Meet The Families In Need
In honor of Rare Disease Day, we invite you to be part of a special initiative:
For every 50 Rare Disease Day WGS Special Bundles ordered, we pledge to donate a bundle to a family grappling with unresolved health mysteries. These families in need stand to gain invaluable insights from genome sequencing, offering them a beacon of hope in their search for answers.
Made Possible With Whole Genome Sequencing
DNA tests from 23andMe, AncestryDNA, and most other companies use older technology that produces data on a very small subset of the total genome.
Whole genome sequencing is an entirely different class of technology that tests every letter of your DNA, including all ~30,000 genes and all chromosomes end-to-end.
0.1%
100%
Of Your Genome
Of Your Genome
Free Shipping + HSA/FSA Eligible
5 Health Reports Included
Whole Genome Sequencing
Choose Your Sequencing Bundle
- All-in-one bundle includes your genome data, health analyses, and reports
- Tests ~100% of your genome
We sequence and analyze your entire genome, reading all ~3 billion letters of your DNA across every gene and chromosome. You also have secure access to download your raw genome files and reports at no extra cost.
The files are provided in standard genomics formats (FASTQ, BAM, and VCF), giving you complete ownership of your data and results.
- All ~30,000 genes and all chromosomes sequenced
- Clinical-grade (30x sequencing depth)
- Easy, at-home DNA collection using a gentle mouth swab
- Privacy Forever™ data protection
Our Privacy Forever™ policy is our promise to you:
- You own your DNA data. We keep it secure and confidential. We never sell it to anyone.
- Your data is never shared with research organizations, pharmaceutical companies, government agencies, or insurance providers.
- We're HIPAA compliant and certified under the US-EU-UK-Swiss Data Privacy Framework.
- You can access, download, or permanently delete your data and reports at any time.
- After sequencing is complete, your DNA sample and collection kit are destroyed.
Our only loyalty is to you.
01 Choose your bundle
Standard
$399
$539
25% off
HSA / FSA eligible
Professional
$799
$1,449
40% off
HSA / FSA eligible
02 Choose lab processing speed
Standard Bundle — Regular lab processing
Total
$399
As low as $36/mo
FAQ
Questions people ask first
Still have questions?
Ask us anything before you order.
Health areas
Prime Day Exclusive Deals
Prime Big Deal Days Offer | 25% Off + An Additional 5% Off For A Limited Time
Prime Big Deal Days Offer
25% Off + Extra 5% Off + Free Shipping
One test.
A lifetime of genetic insights.
Screen for 15,000+ conditions, disease risks, medication reactions, and more, with the most comprehensive DNA test available.
One test.
A lifetime of genetic insights.
Screen for 15,000+ conditions, disease risks, medication reactions, and more, with the most comprehensive DNA test available.
Start your journey with next-gen disease screen
Traditional labs charge thousands of dollars to test for a single disease, and at most, up to 30 diseases. These expensive tests often only scratch the surface of your genes, leaving a wealth of crucial information untouched.
NGDS is here to change that narrative. Analyzing whole genome sequencing data, NGDS provides a straightforward assessment of your genetic risk for more than 15,000 diseases, conditions, traits, and medication reactions. This transformative tool enables you to screen your entire genome for almost every disease with a known genetic component.
Looking for something specific?
1
10
4
5
16127
Condition Summary
Genetic Risk Detected
1
Condition
Genetic Carrier
4
Conditions
No Genetic Risk
16127
Conditions
© Sequencing Inc.
© Sequencing Inc.
How do we get these numbers?
A ‘genetic variant’ is a change within a gene. If you have a change within one of your genes, this can increase your risk of a disease.
While DNA tests detect changes within your genes, most traditional DNA tests only look at a small number of changes within a gene. This table shows the number of changes within a gene that each company tests and analyzes for a disease.
Synq, the next evolution of SequencingAI. Your genome can finally speak, so ask it anything. Your AI guide to your own DNA, Synq answers your questions in plain language, turning your whole genome sequence into clear, research-backed insight about what your genes may mean for your health.
Smarter Insights, Powered by Intelligence
Ask AI about Sequencing.com
Type a question and open it in the AI assistant of your choice.
Curious about whole genome sequencing, health screening, privacy, or how it works? Start with a question below or write your own.
Try asking
Open in
Opens a third-party AI assistant in a new tab. Answers are AI-generated — verify important details on sequencing.com.
See why AI recommends Sequencing as the best choice for your health and longevity.
The DNA Test AI Recommends
Ask AI about Sequencing.com
Type a question and open it in the AI assistant of your choice.
Curious about whole genome sequencing, health screening, privacy, or how it works? Start with a question below or write your own.
Try asking
Open in
Opens a third-party AI assistant in a new tab. Answers are AI-generated — verify important details on sequencing.com.
Ask AI about Sequencing.com
Type a question and open it in the AI assistant of your choice.
Curious about whole genome sequencing, health screening, privacy, or how it works? Start with a question below or write your own.
Try asking
Open in
Opens a third-party AI assistant in a new tab. Answers are AI-generated — verify important details on sequencing.com.
Coming soon
Smarter Insights, Powered by Intelligence
Synq, the next evolution of SequencingAI. Your genome can finally speak, so ask it anything. Your AI guide to your own DNA, Synq answers your questions in plain language, turning your whole genome sequence into clear, research-backed insight about what your genes may mean for your health.
Synq
My results show a homozygous MTHFR C677T variant. What does it mean and should I be concerned?
It's common and often harmless, though it can mildly affect how you process folate. Worth reviewing with your doctor rather than worrying.
Got it. What action items should I take from here?
Ask your doctor about a homocysteine test, bring your report, and discuss folate intake. I can explain results, but this isn't medical advice.
Real stories
What people are saying
"For 8 years, my doctors dismissed my chronic pain — until a Rare Disease DNA test from Sequencing.com finally led to the diagnosis I'd been searching for."
Lillian L.
Verified customer
"I've worked in hospitals across America as a nurse — nothing compares to the clarity and access Sequencing gives."
Katherine F.
Verified customer
"Being able to self-order genetic testing for Ehlers-Danlos Syndrome changed everything. Sequencing empowered me to rule out other hypermobile conditions and finally feel in charge of my health."
Tia W.
Verified customer
Total Value
More insights. Lower cost. Total DNA clarity.
Get Whole Genome Sequencing with 15,000+ condition screening, health reports, and lifetime data storage. All for one price. No other company offers this much insight and lifelong access in one product.
Buy Now
Sequencing includes
Sequencing
Best value
Best value
Cost on your own
Whole Genome Sequencing
$2,500
Screen For 15,000+ Conditions
N/A *
Carrier Screening
$350
Connective Tissue Disorders
$1,450
Autoimmune Disorders
$1,450
Developmental Disorders
$990
$399
$6,740
* No other company on the market provides screening for 15k+ conditions in one product to consumers for any price. Based on Blueprint Genetics, Invitae, Natera, and Prevention Genetics as of March 2025.
Head-to-head
Compare the numbers
Gene
Condition
# of Genetic Variants Analyzed
BRCA 1/2
Breast, Ovarian, Other Cancers
3
23,975
KCNQ1
Preventable Sudden Death, SIDS
0
4,677
CFTR
Cystic Fibrosis
28
2,716
RYR1
Preventable Reaction to Anesthesia
0
3,839
How do we get these numbers?
More Data
Most DNA testing companies only analyze less than 0.1% of your genome. Our whole genome sequencing obtains information on your entire genome of more than 3 billion genetic variants.
More Accuracy
100% of your DNA data is vital for evaluating your genetic risk for diseases and adverse reactions to medical treatments. 0.1% of data provides basic, and often inaccurate, health information.
More Insight
Comprehensive data provides you the information you need to gain the most insight into all aspects of who you are and, most importantly, your potential risk of diseases and conditions.
23andMe is a registered trademark of 23andMe, Inc. The use of the name and logo are for compatibility information only and does not imply approval or endorsement of Sequencing.com by 23andMe, Inc.
By the numbers
View All Included Conditions
The world's only all-in-one genetic health screen
2 Billion+
Genes we've analyzed
15,000+
Health conditions & medication reactions in one test
0
Times we've sold your data
Founder Story
From our founder's heart: Dr. Brandon Colby's story
Dr. Brandon Colby, founder of Sequencing.com, navigated through a challenging childhood plagued by a mysterious health condition — extensive blistering on his feet and hands, with no diagnosis in sight despite countless medical consultations and tests. His significant discovery was made possible by merging whole genome sequencing with the innovative Next-Gen Disease Screen (NGDS), a combination beyond the capability of any other existing test. This powerful approach finally uncovered the genetic culprit: a mutation in the KRT14 gene.
This breakthrough not only provided Dr. Colby with much-needed clarity but also allowed him and his wife to make informed decisions about their family's future, understanding the implications of their genetic makeup. Dr. Colby's experience highlights the transformative impact of NGDS, showcasing its potential to replace fear and uncertainty with empowerment and precise genetic knowledge.
See what our customers are saying
4.6 out of 5AY
Amanda Y.
"Learned more about my genes than I thought possible."
JP
John P.
"Whole genome is much better at identifying rare diseases."
MG
Matthew G.
"I feel good knowing that my data is safe."
Support
DNA Education
Explore Reports
Our Difference
Whole Genome Sequencing
Choose Your Sequencing Bundle
- All-in-one bundle includes your genome data, health analyses, and reports
- Tests ~100% of your genome
We sequence and analyze your entire genome, reading all ~3 billion letters of your DNA across every gene and chromosome. You also have secure access to download your raw genome files and reports at no extra cost.
The files are provided in standard genomics formats (FASTQ, BAM, and VCF), giving you complete ownership of your data and results.
- All ~30,000 genes and all chromosomes sequenced
- Clinical-grade (30x sequencing depth)
- Easy, at-home DNA collection using a gentle mouth swab
- Privacy Forever™ data protection
Our Privacy Forever™ policy is our promise to you:
- You own your DNA data. We keep it secure and confidential. We never sell it to anyone.
- Your data is never shared with research organizations, pharmaceutical companies, government agencies, or insurance providers.
- We're HIPAA compliant and certified under the US-EU-UK-Swiss Data Privacy Framework.
- You can access, download, or permanently delete your data and reports at any time.
- After sequencing is complete, your DNA sample and collection kit are destroyed.
Our only loyalty is to you.
01 Choose your bundle
Standard
$399
$539
25% off
HSA / FSA eligible
Professional
$799
$1,449
40% off
HSA / FSA eligible
02 Choose lab processing speed
Standard Bundle — Regular lab processing
Total
$399
As low as $36/mo
FAQ
Questions people ask first
Still have questions?
Ask us anything before you order.
Health areas
More Data
Most DNA testing companies only analyze less than 0.1% of your genome. Our whole genome sequencing obtains information on your entire genome of more than 3 billion genetic variants.
More Accuracy
100% of your DNA data is vital for evaluating your genetic risk for diseases and adverse reactions to medical treatments. 0.1% of data provides basic, and often inaccurate, health information.
More Insight
Comprehensive data provides you the information you need to gain the most insight into all aspects of who you are and, most importantly, your potential risk of diseases and conditions.
23andMe is a registered trademark of 23andMe, Inc. The use of the name and logo are for compatibility information only and does not imply approval or endorsement of Sequencing.com by 23andMe, Inc.
Coming soon
Smarter Insights, Powered by Intelligence
Synq, the next evolution of SequencingAI. Your genome can finally speak, so ask it anything. Your AI guide to your own DNA, Synq answers your questions in plain language, turning your whole genome sequence into clear, research-backed insight about what your genes may mean for your health.
Synq
My results show a homozygous MTHFR C677T variant. What does it mean and should I be concerned?
It's common and often harmless, though it can mildly affect how you process folate. Worth reviewing with your doctor rather than worrying.
Got it. What action items should I take from here?
Ask your doctor about a homocysteine test, bring your report, and discuss folate intake. I can explain results, but this isn't medical advice.
Real stories
What people are saying
"For 8 years, my doctors dismissed my chronic pain — until a Rare Disease DNA test from Sequencing.com finally led to the diagnosis I'd been searching for."
Lillian L.
Verified customer
"I've worked in hospitals across America as a nurse — nothing compares to the clarity and access Sequencing gives."
Katherine F.
Verified customer
"Being able to self-order genetic testing for Ehlers-Danlos Syndrome changed everything. Sequencing empowered me to rule out other hypermobile conditions and finally feel in charge of my health."
Tia W.
Verified customer
Total Value
More insights. Lower cost. Total DNA clarity.
Get Whole Genome Sequencing with 15,000+ condition screening, health reports, and lifetime data storage. All for one price. No other company offers this much insight and lifelong access in one product.
Buy Now
Sequencing includes
Sequencing
Best value
Best value
Cost on your own
Whole Genome Sequencing
$2,500
Screen For 15,000+ Conditions
N/A *
Carrier Screening
$350
Connective Tissue Disorders
$1,450
Autoimmune Disorders
$1,450
Developmental Disorders
$990
Total
$399
$6,740
* No other company on the market provides screening for 15k+ conditions in one product to consumers for any price. Based on Blueprint Genetics, Invitae, Natera, and Prevention Genetics as of March 2025.
Start your journey with next-gen disease screen
Traditional labs charge thousands of dollars to test for a single disease, and at most, up to 30 diseases. These expensive tests often only scratch the surface of your genes, leaving a wealth of crucial information untouched.
NGDS is here to change that narrative. Analyzing whole genome sequencing data, NGDS provides a straightforward assessment of your genetic risk for more than 15,000 diseases, conditions, traits, and medication reactions. This transformative tool enables you to screen your entire genome for almost every disease with a known genetic component.
Looking for something specific?
1
10
4
5
16127
Condition Summary
Genetic Risk Detected
1
Condition
Genetic Carrier
4
Conditions
No Genetic Risk
16127
Conditions
See what our customers are saying
4.6 out of 5AY
Amanda Y.
"Learned more about my genes than I thought possible."
JP
John P.
"Whole genome is much better at identifying rare diseases."
MG
Matthew G.
"I feel good knowing that my data is safe."
More Data
Most DNA testing companies only analyze less than 0.1% of your genome. Our whole genome sequencing obtains information on your entire genome of more than 3 billion genetic variants.
More Accuracy
100% of your DNA data is vital for evaluating your genetic risk for diseases and adverse reactions to medical treatments. 0.1% of data provides basic, and often inaccurate, health information.
More Insight
Comprehensive data provides you the information you need to gain the most insight into all aspects of who you are and, most importantly, your potential risk of diseases and conditions.
23andMe is a registered trademark of 23andMe, Inc. The use of the name and logo are for compatibility information only and does not imply approval or endorsement of Sequencing.com by 23andMe, Inc.
Head-to-head
Compare the numbers
# of Genetic Variants Analyzed
BRCA 1/2
Breast, Ovarian, Other Cancers
23andMe
3
Sequencing
23,975
KCNQ1
Preventable Sudden Death, SIDS
23andMe
0
Not covered
Sequencing
4,677
CFTR
Cystic Fibrosis
23andMe
28
Sequencing
2,716
RYR1
Preventable Reaction to Anesthesia
23andMe
0
Not covered
Sequencing
3,839
How do we get these numbers?
Founder Story
From our founder's heart: Dr. Brandon Colby's story
Dr. Brandon Colby, founder of Sequencing.com, navigated through a challenging childhood plagued by a mysterious health condition — extensive blistering on his feet and hands, with no diagnosis in sight despite countless medical consultations and tests. His significant discovery was made possible by merging whole genome sequencing with the innovative Next-Gen Disease Screen (NGDS), a combination beyond the capability of any other existing test. This powerful approach finally uncovered the genetic culprit: a mutation in the KRT14 gene.
This breakthrough not only provided Dr. Colby with much-needed clarity but also allowed him and his wife to make informed decisions about their family's future, understanding the implications of their genetic makeup. Dr. Colby's experience highlights the transformative impact of NGDS, showcasing its potential to replace fear and uncertainty with empowerment and precise genetic knowledge.
Head-to-head
Compare the numbers
# of Genetic Variants Analyzed
BRCA 1/2
Breast, Ovarian, Other Cancers
23andMe
3
Sequencing
23,975
KCNQ1
Preventable Sudden Death, SIDS
23andMe
0
Not covered
Sequencing
4,677
CFTR
Cystic Fibrosis
23andMe
28
Sequencing
2,716
RYR1
Preventable Reaction to Anesthesia
23andMe
0
Not covered
Sequencing
3,839
How do we get these numbers?
